Cardioprotective Activity of Fruit of Lagenaria siceraria (Molina) Standley on Doxorubicin Induced Cardiotoxicity in Rats

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Beneficial effects of Lagenaria siceraria (Mol.) Standley fruit epicarp in animal models.

Lagenaria siceraria (Mol.) Standley fruit (bottle gourd), a commonly used vegetable in India is described as cardiotonic and as a general tonic in Ayurveda. Keeping in view the presence of free radical scavenging activity in L. siceraria and involvement of free radicals in the development of various disorders, present studies were designed to evaluate the ethanolic extract of L. siceraria fruit...

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The present study was designed to evaluate the cardioprotective effects of Lagenaria siceraria fruit juice in isoproterenol-induced myocardial infarction. Rats injected with isoproterenol (200 mg/kg, s.c.) showed a significant increase in the levels of serum uric acid, tissue Na(++) and Ca(++) ions and membrane-bound Ca(+2)-ATPase activity. A significant decrease in the levels of serum protein,...

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Effect of Lagenaria siceraria fruit powder on sodium oxalate induced urolithiasis in Wistar rats

BACKGROUND In spite of advances in the present practice of medicine, the formation and growth of calculi continues to trouble mankind, as there is no satisfactory drug to treat kidney stones. In India, many indigenous drugs are in use for the treatment of urinary calculus disease. OBJECTIVE The present study was intended to determine anti-urolithiatic effect of Lagenaria siceraria fruit powde...

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Background: Cardiovascular diseases are the major death causing disease worldwide and identification of herb based therapeutics is the need of today. Present study was undertaken to evaluate the cardioprotective activity of Momordica dioca Roxb. (MDR) fruit extract on doxorubicin (DXR) induced cardiotoxicity on rats. Methods: The crude methanolic extract (MEMD) was prepared by soxhlet extractio...

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ژورنال

عنوان ژورنال: International Journal of Pharmacology

سال: 2008

ISSN: 1811-7775

DOI: 10.3923/ijp.2008.466.471